Antibiotic-resistant bacteria in hospitalized patients with bloodstream infections: analysis of some associated factors

Blood infections are life-threatening if not detected and managed properly. This study investigates the correlation between fever and previous antibiotics therapy with differential time to positivrty [DTP] at admitted patients at Nemazee Hospital in Shiraz, southern Iran. From January 2005 to December 2006, 985 positive blood samples in Bactec bottles from the admitted patients at Nemazee Hospital were analyzed. Sensitivity patterns of the bacteria to a panel of antibiotics were determined by the disk diffusion method. S. epidermidis, S. aureus and Acinetobacter were the most prevalent isolates respectively. However, only 100 [20.7%] S. epidermidis samples were the true infections. The most susceptible Gram positive and negative bacteria were S. viridance, S. aureus, H. influenzae, and Brucella spp., respectively. Imipenem, amikacin and ciprofloxacin were the effective ones against Gram negative bacteria, while vancomycin, co-amoxiclav and chloramphenicol were effective against Gram positive ones. Cefuroxime and penicillin G were less effective antibiotics against both Gram negative and positive bacteria. As demonstrated, the combined prescription of vancomycin and imipenem seems to cover the majority of infective agents in the blood whenever an empirical therapy is to be initiated. Moreover, periodic surveillance of antibacterial susceptibility patterns is warranted

Subjective lactose intolerance in apparently healthy adults in southern Iran: Is it related to irritable bowel syndrome?

BACKGROUND: The main symptoms of lactose intolerance are bloating, abdominal cramps, increased flatus and loose watery stools. These symptoms are similar to those of irritable bowel syndrome (IBS), which is a prevalent entity in the community. OBJECTIVE: As there was no data available on the prevalence of LI and the correlated factors, this study aimed to determine these correlations and their relation to IBS symptoms in an apparently healthy population in Shiraz, southern Iran. MATERIALS AND METHODS: A survey among 1,978 individuals older than 35 years was conducted in Shiraz, southern Iran, using a questionnaire that consisted of items regarding demographic data, life style, subjective gastrointestinal symptoms of LI and IBS symptoms according to ROME II criteria. RESULTS: A total of 562 subjects reported LI (28.41%). The prevalence was significantly higher in females, in subjects taking NSAIDs or acetaminophen and in cases reporting IBS symptoms. Subjects with LI avoided certain foods and drinks; and in order to relieve their symptoms, they used OTC drugs, herbal medicine or visited a physician. On the other hand, no relation was found between LI and age, smoking or the number of meals per day. CONCLUSIONS: Although we found that individuals with IBS had significantly more subjective LI than those without IBS, in the absence of documented lactose malabsorption, it is hard to tell whether the reported symptoms indeed are those of LI or simply those of IBS. So, a period of dairy product avoidance and/ or requesting a test for lactose malabsorption may be beneficial in this area.

Current substance use in patients with gastric cancer in Southern Iran.

BACKGROUND: Psychiatric disorders may affect patients suffering from cancer and substance use disorders. OBJECTIVE: This study was undertaken to evaluate the prevalence of tobacco and opioid use in patients with gastric cancer in Shiraz, Fars Province and Southern Iran. MATERIALS AND METHODS: In a hospital survey of 177 gastric cancer patients aged 24 years and more, a semistructured-interview was performed based on SDM-IV criteria during the year 2003. RESULTS: The mean age of the patients was 58.13 (SD = 14.03) years. Among the subjects, 50.9% (90) were tobacco dependent (61.5% men and 29.4% women, P < 0.001), while 10 (5.7%) were opioid-dependent (7.3% men and 1.9% women, P = 0.16). Tobacco and opioid-dependency were not significantly related to age groups, economical or occupational status. Mean ages of tobacco and opioid-dependants were not significantly different from nondependants. CONCLUSIONS: Tobacco and opioid dependency were common problems among gastric cancer patients. This report provides useful information for health planning. Men were at greater risk than women. Treatment programs should focus on all age-groups, all occupations and all income-levels.